Who We Are

HeaYeon Lee, Ph.D.

President and CEO
Mara Nanotech New York, Inc., USA

Visiting Scholar, Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, Boston, MA

Adjunct Professor, College of Human Ecology,
Chungnam Nat'l University,
South Korea

160 Convent Ave.,
Steinman Hall, RM B20,
New York, NY 10031-9101, US
TEL 781-999-2285
Email h.lee@mara-nanotech.com

We have worked on digital nanobiomedical sensor system using electrochemical analysis and nanocosmeceudical with nanotechnology, nanobioscience, chemistry, material science and molecular engineering. Our company goal is to make nano-bio-diagnostic kits/system using nanowell array technology for health monitoring and nanocosmeceutical for skin health care. It is applicable in clinical medicine, skin healthcare, pharmacology, environmental industry.

Note that most hot issues in nanobiomedical technology, such as single biomolecule sensing devices, are still unsettled. I believe that a key solution to those issues could come from a nanoscale well array (NWA), which I have already proposed. Over the past 15 years, I have successfully fabricated a NWA structure using various nanofabrication methods and demonstrated that it can be used to fabricate a new nano-biosensor with ultra-high sensitivity and good reproducibility.

The geometry permits only one (or a few biomolecules) to enter and become attached to a nanosized substrate. When this array is applied to highly sensitive electrochemical DNA detection, a 150-orders-of-magnitude enhancement in sensitivity is obtained. This NWA system can be applied to numerous other integrated digital biomedical sensors. I have published several papers in important journals, and I have also been invited to several international conferences to give invited presentations. Most of these research results were generated from ideas I proposed myself.

HeaYeon Lee is a President/CEO in Mara Nanotech New York, Inc. and a Visiting Professor, Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, Boston, MA.
She received her BS (1987) and MS degrees (1990) in Chemistry from Pukyong National University, South Korea and her Ph.D. degree (1995) in Chemistry from Osaka University, Japan. After finishing advanced degrees in nanofabrication and characterization technologies, she has been working on developing new nanobioelectronic devices and nanobiosensors. She was a Designated Professor at the Institute of Scientific and Industrial Research, Osaka University, and Research Associate Professor of Mechanical and Industrial Engineering at Northeastern University, Boston, USA. Her research work has been contributing to accelerating cutting-edge research in the emerging bio-nanoscience area.

View Dr. HeaYeon Lee's Bio

View Patents

What We Do

We can develop a new class of diagnostic approach using nanotechnology for detection of an aging-associated disease biomarkers that have the potential to
revolutionize early diagnoses and therapeutic approaches.
We are focusing on development nanocosmeceutical against radical generation on the skin for antiaging.

Toward Nano-Bio-Science & Technology

H.Y.Lee et al, Advanced Materials, 20, 31(2008), Small, 4, 342(2008), Lab on a chip, 9, 132 (2009)

H.Y.Lee et al, Appl.Phys.Lett., 81,1318 (2002), J.Korean Phys.Soc, 37, 475(2000), J.Appl.Phys. 8, 3601(1996)

Nanomedicine is...
" Nanoscience for Health "
through successful integration into
diagnosing, treating and preventing diseases
by understanding of the functions of human body
on the molecular level.

- Europian scientific foundation

Basic Concept of Our Research

Control of individual molecular reactions in confined nanospace

H.Y.Lee et,al JACS (2005), Langmuir (2005), Lab on a chip (2006), Appl.Phys.Lett. (2006), Advanced Materials (2008) -The Highlight, Small (2008)

H.Y.Lee et.al.Japanese Patents 3972096 (2008); 4324707 (2009); 4497903 (2009)

Nanowell Array (NWA)
For putting biomolecuels at designated positions within the nanoscale-sized wells

Highly sensitive, selective and specific biosensors for biomolecular analysis

How We Do It

The focus on electrochemical nanowell array sensor system as my research achievement for medical applications will have commercialization in early detection and prevention of Alzheimer's disease, cardiovascular disease, hypertension, diabetes. Early detection and effective management of risk factors can be inexpensive and effective ways of controlling future health care costs at very old ages. Also advances are expected to lead to innovative therapeutic techniques and new approaches to the prevention of medical conditions on age-related diseases.

Furthermore we'll realize visionary ideas grounded in significant real-world needs the research product integrated with my esthetics licence. Our company will act as bridge of large gap between research and application and create a synergy in academy and experience base between healthcare scientists and technologists.

Advantages of NWA for Digital Nanobiosensor

Traditional macroelectrode

Low S/N ratio

• The scale difference between macroelectrodes and molecules is tremendous.

• Background noise from electrode surface will be very large.

Nanowell array electrode

High S/N ratio

• Background noise can be dramatically reduced.

• Can magnify signal for statistical reliability.

• Can be combined with other electrocatalytic processes to magnify the signal further.

H.Y.Lee et,al Japanese Patent 3972096(2008), Japanese Patent
4324707(2009), Japanese Patent 4497903(2009)

Highly sensitivity by chemical reaction control

Advantage of Electrochemical Assay

• Rapid detection

• Easily scaled down

• Compatible with computer

• Simple and easy to measure

• Sensitivity

• Real time monitoring

• Economical biodevice

• Simultaneous measurements of several samples.

Collaborators

Jonghan Kim, Ph.D.

Assistant Professor of Toxicology and Pharmacokinetics
Department of Pharmaceutical Sciences School of Pharmacy, Bouve College of Health Sciences Northeastern University

360 Huntington Avenue, 148 TF
Boston, MA 02115
TEL 617-373-5943 FAX 617-373-8886
EMAIL j.kim@neu.edu

Hak Soo Choi, Ph.D.

Associate Professor of Medicine, Harvard Medical School
P.I., Division of Hematology-Oncology, Beth Israel Deaconess Medical Center (BIDMC)
Harvard Medical Faculty Physicians at BIDMC Faculty, Dana-Farber/Harvard Cancer Center Faculty, Cancer Research Institute, BIDMC

330 Brookline Avenue, Room SL-418
Boston, MA 02215
TEL 617-667-6024 FAX 617-667-0214
EMAIL hchoi@bidmc.harvard.edu

View 2017 Representative paper

View 2018 Representative paper